When Charles Darwin came up with his incredible theory of evolution, he managed to explain a lot about where we came from and how we became the species we are now. So he answered the WHERE and HOW pretty darn well.
However there is one thing that he did not answer, and to the best of my knowledge has never been answered before. That is the WHY. In specific:
Why do cells want to survive and reproduce? What drives this need?
Evolution is the adjustments made to survive. But for what purpose? What is the end goal? And what gives a small, simple construct like a cell the drive and motivation to want to survive. Is it chemical or metaphysical?